Fibrin Suspension Assay for Fibrinolytic Activity
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چکیده
منابع مشابه
Fibrin Suspension Assay for Fibrinolytic Activity
By A. E. D R AND D. Ku ui A GROWING INTEREST in fibrinolytic agents has given rise to a variety of methods for assessing the activity of such agents in vitro. The fibrin plate assay1 is a useful technic employing the natural substrate. Other methods,2 using formed fibrin clots, have also been devised, as well as technics employing other substrates such as casein. The purpose of this study was t...
متن کاملFibrin Suspension Assay for Fibrinolytic Activity.
By A. E. D R AND D. Ku ui A GROWING INTEREST in fibrinolytic agents has given rise to a variety of methods for assessing the activity of such agents in vitro. The fibrin plate assay1 is a useful technic employing the natural substrate. Other methods,2 using formed fibrin clots, have also been devised, as well as technics employing other substrates such as casein. The purpose of this study was t...
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ECENT YEARS have brought increased appreciation of the importance of the role of fibrinolysis in the regulation of normal hemostasis and in the production of abnormal bleeding. The mechanisms by which active fibrinolysis is induced are far from clear, but it does seem likely that it can be brought about by shock,1 severe emotional stress,2 injection of adrenalin,2 anoxia3 and liberation of acti...
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Most tissues exhibit fibrinolytic activity because of their content of plasminogen activator (Albrechtsen, 1958; Astrup and Stage, 1952; Pandolfi, Nilsson, Robertson, and Isacson, 1967; Sayers, Tyler, and Lack, 1965). This activity might be demonstrated by applying the tissue itself or a tissue extract on a fibrin plate (Astrup and Permin, 1947; Caughey and Highton, 1967) or by the histiochemic...
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125I-fibrinogen, adsorbed to polystyrene tubes at low ionic strength and treated with thrombin, serves as a substrate for a rapid, convenient, and sensitive test tube assay for plasmin and activators and inhibitors of this enzyme. 125I-labeled digestion products released from the 125I-fibrin-polystyrene matrix are readily separated and quantitated and behave, on gel permeation, in the same mann...
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ژورنال
عنوان ژورنال: Blood
سال: 1964
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v23.6.729.729